For the past seven years Ive been playing guitar through Guitar Rig software and using the Guitar Rig interface pedal. Over time, the hardware and software have become obsolete. With the OSX Sierra upgrade, my pedal / audio interface is no longer supported. I am looking to get rid of anything that is software/computer based and go with analog hardware. I consider myself a hobbyist so I dont play professionally and rarely play in public. I record occasionally but not a lot. I have always played through FRFR speakers. I use professional [self-powered] studio monitors with Guitar Rig and my laptop. I also have a pair of JBL EON615 PA speakers that sound good in a small auditorium. Id like to continue to use this equipment with my new solution. Here is my question: If I purchase a Marshall In A Box pedal (something like the Wampler Plexi-Drive Deluxe) and a few other effects pedals, can I plug into a DI/Cab Sim box then to my Mackie mixer and out to powered speakers and have it sound OK? I just dont know how it will sound not having a conventional guitar power amp.