I usually have the tone knob at least 3:00 without the boost engaged, lower if it is. Depth often is full up, or close (the most bass), and Texture is off (the most treble and harmonics). These are clean settings, which is how I usually use the amp (with or without dirt pedals). For your own settings, I'd suggest playing around and exploring by ear. Settings are dependent of the guitar, the cab and speaker (I'm using a head), tubes, preferences, other rig settings, etc. In the ideal situation, I'd start with the tone controls set flat (and I have no idea what those settings might be with your modified tone stack). Then I'd try to balance the amp's highs and lows. Then I'd set the mids.* Then I'd repeat, as things will interact -- it's an iterative process. Beyond that, I'd use the guitar I'm tuning things for. For an LP, I usually tune to the neck pickup with pickup's volume on 7.5-8 and the tone on 10, for the brightest tone I want from the neck. If you can't get what you want from the amp with similar tuning techniques, you may want to try an EQ pedal. Sometimes a speaker swap is necessary.** Sometimes a particular amp isn't the right tool for the specific job. To me, the most important thing is getting a clean tone I like. The rest can be done with pedals, if necessary. Others will have different thoughts on this. * If you can't get enough mids when the mids control is maxed, or when there is no mids control, try turning down both the treble and bass. ** I haven't heard the stock speaker, or the combo at all. The stock speaker supposedly is pretty good. Speakers can have a relatively strong effect on the overall sound, but that's another adventure.