+1 Choice of a handgun is just as individual as choice of a guitar. My home-defense gun: I like .45 ACP. Stopping power is great and 230gr is subsonic. A flashlight mounted on the pistol is a big plus for a home defense gun (as long as you're sticking a flashlight on, you might as well get one with a laser). If you ever fire a pistol in an enclosed area, you'll appreciate a suppressor. You don't want hearing damage just because some jackass broke into your house. Tritium sights are also a plus.