I was (over?)thinking about this the other day. Do the mixed gauge string sets (heavy low strings with light high strings) that manufacturers sell put uneven stress on a guitar neck? If so, are there any negative side effects to having more string tension on one side of the neck than the other? A heavier gauge string will require more tension to tune to the same note as a lighter gauge string due to the increased mass - I think. Am I just over analyzing this?