[Splattle101]

And:

Before I forget again, there's one thing about the middle setting that I forgot to mention. It’s a lot easier to use than it sounds to describe it!

If you set your neck so it’s basically clean (~ 50%), and then set the bridge to about 75%, that will give you the sounds-like-the-bridge-pickup-but-fuller tone. As I said before, that’s a good rhythm or lead sound.

From that basic position, if you want to get a boost, all you have to do is adjust ONE volume control up to 100%. Either will work. If the bridge, you get the biting sound, if the neck you get the fuller sound. When you’ve finished, simply turn that volume back to where it was.

Simple.

In other words, once you’ve worked out your pre-sets, using the Les Paul this way is as simple as playing a Telecaster.