Re: Do different Pickups really make a difference?
the epis are fine - especially in the neck position which is what slash uses.
How about playing and technique? If slash, eddie, warren haynes or jeff beck pick up a cheapas ibanez starter pack, they will sound better than many of us here would sound on our wet dream set up...hands down. These guys got good by practicing, not parting. and when you get good, you can hire a tech to worry about your pickups for you.
That being said, I agree with most here - go for an amp first if you feel like throwing some money around, tubes are nice...but those line 6 amps are not all that bad. you could sound great on that setup if you pour your heart into playing. You can make that guitar sound just like slash, not by changing pickups - but by practice practice. When you start to sound like your faves through your current gear, then worry about gear.
Guitar - Amp - Suds